Vitamin D3 Analogues with Low Vitamin D Receptor Binding Affinity Regulate Chondrocyte Proliferation, Proteoglycan Synthesis, and Protein Kinase C Activity

The purpose of the study was to determine the genomic and nongenomic mechanism of action of various analogues of vitamin D on resting zone (RC) and growth zone (GC) rat costochondral chondrocyte differentiation and proliferation in vitro. This study is intended to provide insight into how modifications of the A-ring and other structural modifications of vitamin D molecule affect the biological activity of these secosteroids.Air Force Inst of Tech Wright-Patterson AFB OH is the author of 'Vitamin D3 Analogues with Low Vitamin D Receptor Binding Affinity Regulate Chondrocyte Proliferation, Proteoglycan Synthesis, and Protein Kinase C Activity', published 1997 under ISBN 9781423579397 and ISBN 1423579399.