Toxicology and Carcinogenesis Studies of Bromodichloromethane No 75-27-4) in Male F344/N Rats and Female B6C3Fi Mice

Bromodichloromethane (BR) is a by-product of the chlorination of drinking water. It has been shown to be carcinogenic at multiple sites in rats & in mice after administration by gavage in corn oil. To further characterize its dose-response relationships for eval. of human risk, BR was nominated for toxicity & carcinogenicity studies in rats & mice by drinking water exposure. Male F344/N rats & female B6C3F1 mice were exposed to BR in drinking water for 3 weeks or 2 years. Genetic toxicology studies were conducted in Salmonella typhimurium, L5178Y mouse lymphoma cells, cultured Chinese hamster ovary cells, mouse bone marrow cell, & mouse peripheral blood erythrocytes. None of these studies showed evidence of carcinogenic activity. Illustrations.Melnick, R. L. is the author of 'Toxicology and Carcinogenesis Studies of Bromodichloromethane No 75-27-4) in Male F344/N Rats and Female B6C3Fi Mice', published 2006 under ISBN 9781422306338 and ISBN 142230633X.