Toxicology and Carcino Genesis Studies of 2 - Methylimidazole in F344/N Rats and B6C3F1 Mice

2-Methylimidazole is used in the manufacture of pharmaceuticals, photographic chemicals, dyes & pigments, ag. chemicals, & rubber. It has been identified as a byproduct in foods & has been detected in mainstream & sidestream tobacco. smoke. 2-Methylimidazole was nominated by the Nat. Cancer Institute for a long-term study because of the high potential for human exposure & a lack of carcinogenicity studies in rodents. Male & female F2344/N rats & B6C3F1 mice were exposed to 2-methylimidazole (99.5% pure) in feed for 2 years. Chapters: Explanation of levels of evidence of carcinogenic activity; Tech. Reports Review Subcomm. & Summary of their comments; Intro.; Materials & Methods; Results; Discussion & Conclusions. Illus.Chan, P. C. is the author of 'Toxicology and Carcino Genesis Studies of 2 - Methylimidazole in F344/N Rats and B6C3F1 Mice', published 2005 under ISBN 9780756746865 and ISBN 0756746868.