Presents an overview of the development of paclitaxel as an anticancer drug, including the discovery, initial development, current status, supply issues, and recent clinical developments. Discusses in detail the cellular mechanism of action and the toxicity of paclitaxel. Presents drugdelivery and taxotere metabolism. Explains semisynthetic and medicinal chemistry studies. Covers approaches to the total synthesis of paclitaxel.Georg, Gunda I. is the author of 'Taxane Anticancer Agents: Basic Science and Current Status' with ISBN 9780841230736 and ISBN 0841230730.