Skin Carcinogenesis : Mechanisms and Human Relevance

Partial table of contents: CELLULAR AND MOLECULAR ASPECTS. Human Epidermal Keratinocyte Cell Culture and Xenograft Systems: Applications in the Detection of Potential Chemical Carcinogens and the Study of Epidermal Transformation (J. Rheinwald). Consequences of Exposure to Initiating Levels of Carcinogens in Vitro and in Vivo: Altered Differentiation and Growth, Mutations, and Transformation (S. Yuspa, et al.). BIOCHEMICAL ASPECTS. Regulation of Ornithine Decarboxylase in Normal and Neoplastic Mouse and Human Epidermis (T. O2Brien, et al.). Role of Free Radicals in Tumor Promotion and Progression (T. Kensle,r et al.). Diversity in the Chemical Nature and Mechanism of Response to Tumor Promotors (H. Fujiki, et al.). APPLICATIONS. Developing Design Standards for Dermal Initiation/Promotion Screening Studies (W. Eastin, Jr). Experience Gained by the Petroleum Industry in the Conduct of Dermal Carcinogenesis Bioassays (R. McKee, et al.). Application of Short-Term Assays by the Petroleum Industry to Identify Skin Carcinogens (F. Thomas & B. Simpson). Viewpoints and Critical Issues. Index.Slaga, Thomas J. is the author of 'Skin Carcinogenesis : Mechanisms and Human Relevance', published 1989 under ISBN 9780471513131 and ISBN 047151313X.