Genetically Modified Model Report on the Toxicology Studies of Trimethylolpropane Triacrylate

Trimethylpropane triacrylate (TT) is a multifunctional monomer used in the prod'n. of ultraviolet-curable inks & coatings, electron beam irrad'n.-curable coatings, & radiation-cured & photocurable castings of urethanes & epoxy resins, & as an ingred. in many other items such as acrylic glues, polyester, fiberglass, indust'l. baked coatings, & polymer-impregnated concrete. TT was nominated for testing due to its high prod. vol. & use, its potential for consumer exposure, & a lack of adequate test. Conclusions: Male & female Tg.AC hemizygous mice dosed with TT for 6 mon. had increased incidences & multiplicity of papillomas of the skin at the site of dermal appl'n. Treatment-related squamous cell carcinomas occurred at the site of appl'n. in dosed female mice.Chhabra, R. S. is the author of 'Genetically Modified Model Report on the Toxicology Studies of Trimethylolpropane Triacrylate', published 2006 under ISBN 9781422304792 and ISBN 1422304795.