5484720
9780195061062
DNA Topoisomerases are a unique class of enzymes that are responsible for the control and modification of DNA topology (tertiary structure); one example of their function is the transformation of chromosomes from a supercoiled condensed state to uncoiled strands and vice versa. They are of interest both for their intrinsic role in cell biology (i.e. control of cell division) and also because some anticancer drugs, such as camptothecin, act by inhibiting their action.Potmesil, Milan is the author of 'DNA Topoisomerases in Cancer', published 1991 under ISBN 9780195061062 and ISBN 0195061063.
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