Biochemistry of Redox Reactions

In the present volume, the first in the Series The Metabolism of Drugs and Other Xenobiotics, Professor Testa discusses the molecular and biochemical aspects of reactions of oxidation and reduction. While an encyclopaedic treatment is avoided, the covered topics include biochemical properties of the enzymes/isoenzymes, drug-enzyme interactions, the various chemical reactions catalyzed by the enzyme (s), reaction mechanisms and catalytic cycles, regio- and stereoselectivities, structure-metabolism relationships, the reactivity of metabolic intermediates and molecular aspects of toxication and detoxication, as well as molecular mechanisms of direct and indirect enzyme inhibition. The classification of matters is based firstly on enzymes and their reactions, and secondly on the types of target groups being transformed, with carefully selected examples illustrating the reactions under discussion. Such a treatment has heuristic value since it renders the reader capable of educated guesses on the metabolism of other or novel drugs. Forthcoming volumes in the Series will present reactions of hydration and conjugation, and the biological regulations and consequences of xenobiotic metabolism.Testa, Bernard is the author of 'Biochemistry of Redox Reactions', published 1995 under ISBN 9780126853919 and ISBN 0126853916.